产品货号：
Z37819
中文名称：
FYN抗体
英文名称：
Anti-FYN Antibody (Clone#1302CT390.118.237)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FYN Antibody (Clone#1302CT390.118.237) |
| 指标别名 | FYN;p59 Fyn;Proto oncogene c Fyn;Proto oncogene Syn;SLK;Src like kinase;SYN;Tyrosine protein kinase Fyn |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | IHC,FCM,WB |
| 基因名称 | FYN |
| 克隆号 | 1302CT390.118.237 |
| 抗体来源 | Mouse |
| 免疫原 | This FYN antibody is generated from a mouse immunized with a recombinant preotein from human FYN. |
| 计算分子量 | 61kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival,cell adhesion,integrin-mediated signaling,cytoskeletal remodeling,cell motility,immune response and axon guidance.Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain.Following activation by PKA,the protein subsequently associates with PTK2/FAK1,allowing PTK2/FAK1 phosphorylation,activation and targeting to focal adhesions.Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin).Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT.Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage.Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1,KIRREL and TRPC6.Plays a role in neural processes by phosphorylating DPYSL2,a multifunctional adapter protein within the central nervous system,ARHGAP32,a regulator for Rho family GTPases implicated in various neural functions,and SNCA,a small pre-synaptic protein.Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation.Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1,thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts.CSK maintains LCK and FYN in an inactive form.Promotes CD28-induced phosphorylation of VAV1. |
| Uniprot ID | P06241 |
相关搜索：FYN抗体，FYN单抗，Anti-FYN Antibody (Clone#1302CT390.118.237)